The German quality-control methodology was copied by government serum institutes all over the world, and they also obtained the standard serum from Frankfurt.
This was followed by investigations on the "inheritance" of acquired immunity. He also demonstrated, inthat antibodies are passed in breast milk from mother to newborn. He also established, with A. Salvarsan and Neosalvarsan retained their role as the most effective drugs for treating syphilis until the advent of antibiotics in the s.
Manufactured by Hoechst AG, Salvarsan became the most widely prescribed drug in the world. Hematological staining[ edit ] In the early s, Ehrlich's cousin Karl Weigert was the first person to stain bacteria with dyes and to introduce aniline pigments for histological studies and bacterial diagnostics.
In order to determine the effectiveness of diphtheria antiserum, a stable concentration of diphtheria toxin was required.
Among the arsenical drugs already tested for other purposes was one, the th of the series tested, which had been set aside in as being ineffective. In an unheard-of transaction, the manufacturer with whom Ehrlich had collaborated closely, Farbwerke-Hoechstreleased a total of 65, units gratis to physicians all over the globe.
His model was on the one hand the impact of quinine on malaria, and on the other hand, in analogy to serum therapy, he thought there must also be chemical pharmaceuticals which would have just as specific an effect on individual diseases.
Ehrlich supposed that living cells have side chains—a shorter chain or group of atoms attached to a principal chain in a molecule—much in the way that dye molecules were known to have side chains that were related to their coloring properties.
He injected the dyes alizarin blue and indophenol blue into laboratory animals and established after their death that various organs had been colored to different degrees. These were also evaluated at the institute, as was tuberculin and later on various vaccines.
When he returned to Berlin inthe disease had been permanently arrested.