A biography of paul ehrlich and his career as a scientist

The German quality-control methodology was copied by government serum institutes all over the world, and they also obtained the standard serum from Frankfurt.

A biography of paul ehrlich and his career as a scientist

The search for a chemotherapia specifica[ edit ] Before the Institute of Experimental Therapy had moved to Frankfurt, Ehrlich had already resumed work on methylene blue. Among the results achieved by Ehrlich and his research colleagues was the insight that when tumors are cultivated by transplanting tumor cells, their malignancy increases from generation to generation. More testing revealed that Salvarsan was actually more successful if administered during the early stages of the disease. Friendship with Robert Koch[ edit ] Robert Koch, around When a student in Breslau, Ehrlich was given an opportunity by the pathologist Julius Friedrich Cohnheim to conduct extensive research and was also introduced to Robert Koch , who was at the time a district physician in Wollstein, Posen Province. From this date on, the two men were bound in friendship. Additionally, he worked on diverse microbial cell systems and developed a precursor technique to the Gram staining of bacteria. In Ehrlich's view, an added benefit was that methylene blue also stained the long appendages of nerve cells, the axons. The concept of a "magic bullet" has to some extent been realized by the development of antibody-drug conjugates a monoclonal antibody linked to a cytotoxic biologically active drug , as they enable cytotoxic drugs to be selectively delivered to their designated targets e.

This was followed by investigations on the "inheritance" of acquired immunity. He also demonstrated, inthat antibodies are passed in breast milk from mother to newborn. He also established, with A. Salvarsan and Neosalvarsan retained their role as the most effective drugs for treating syphilis until the advent of antibiotics in the s.

Manufactured by Hoechst AG, Salvarsan became the most widely prescribed drug in the world. Hematological staining[ edit ] In the early s, Ehrlich's cousin Karl Weigert was the first person to stain bacteria with dyes and to introduce aniline pigments for histological studies and bacterial diagnostics.

paul ehrlich facts

In order to determine the effectiveness of diphtheria antiserum, a stable concentration of diphtheria toxin was required.

Among the arsenical drugs already tested for other purposes was one, the th of the series tested, which had been set aside in as being ineffective. In an unheard-of transaction, the manufacturer with whom Ehrlich had collaborated closely, Farbwerke-Hoechstreleased a total of 65, units gratis to physicians all over the globe.

His model was on the one hand the impact of quinine on malaria, and on the other hand, in analogy to serum therapy, he thought there must also be chemical pharmaceuticals which would have just as specific an effect on individual diseases.

Ehrlich supposed that living cells have side chains—a shorter chain or group of atoms attached to a principal chain in a molecule—much in the way that dye molecules were known to have side chains that were related to their coloring properties.

He injected the dyes alizarin blue and indophenol blue into laboratory animals and established after their death that various organs had been colored to different degrees. These were also evaluated at the institute, as was tuberculin and later on various vaccines.

When he returned to Berlin inthe disease had been permanently arrested.

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Paul Ehrlich () and the Birth of Molecular Medicine